CST Meets Shelterin to Keep Telomeres in Check - ENS de Lyon - École normale supérieure de Lyon Accéder directement au contenu
Article Dans Une Revue Molecular Cell Année : 2010

CST Meets Shelterin to Keep Telomeres in Check

Résumé

Telomere protection in budding yeast requires the heterotrimer named CST (for Cdc13-Stn1-Ten1). Recent data show that CST components are conserved and required for telomere stability in a wide range of eukaryotes, even those utilizing the shelterin complex to protect their telomeres. A common function of these proteins might be to stimulate priming at the C-strand gap that remains after telomerase elongation, replication termination, and terminal processing. In light of the budding yeast situation, another conserved function of CST might well be the regulation of telomerase. The cohabitation at telomeres of CST and shelterin components highlights the complexity of telomere biology.
Fichier non déposé

Dates et versions

ensl-00815741 , version 1 (19-04-2013)

Identifiants

  • HAL Id : ensl-00815741 , version 1

Citer

Marie-Josèphe Giraud-Panis, M. Teresa Teixeira, Vincent Géli, Eric Gilson. CST Meets Shelterin to Keep Telomeres in Check. Molecular Cell, 2010, 39 (5), pp.665-676. ⟨ensl-00815741⟩
37 Consultations
0 Téléchargements

Partager

Gmail Facebook X LinkedIn More