Article Dans Une Revue Medicine Année : 2016

Clostridium difficile infection in a French university hospital: Eight years of prospective surveillance study

Résumé

The epidemiology of Clostridium difficile infection (CDI) has changed with an increase in incidence and severity. Prospective surveillance was therefore implemented in a French university hospital to monitor the characteristics of patients at risk and to recognize local trends. Between 2007 and 2014, all hospitalized patients (>=18 years) with CDI were included. During the survey, the mean incidence rate of CDI was 2.9 per 10,000 hospital-days. In all, 590 patients were included. Most of the episodes were healthcare-associated (76.1%). The remaining cases were community-acquired (18.1%) and unknown (5.9%). The comparison with healthcare-associated cases showed that the community-acquired group had a lower rate of antimicrobial exposure (P?\textless?0.001), proton pump inhibitor (P?\textless?0.001), and immunosuppressive drugs (P = 0.02). Over the study period, death occurred in 61 patients (10.3%), with 18 (29.5%) being related to CDI according to the physician in charge of the patient. Active surveillance of CDI is required to obtain an accurate picture of the real dimensions of CDI.
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Dates et versions

hal-01910929 , version 1 (10-01-2025)

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Nagham Khanafer, Luc Oltra, Monique Hulin, Olivier Dauwalder, Francois Vandenesch, et al.. Clostridium difficile infection in a French university hospital: Eight years of prospective surveillance study. Medicine, 2016, 95 (23), pp.e3874. ⟨10.1097/MD.0000000000003874⟩. ⟨hal-01910929⟩
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