Does type-I interferon drive systemic autoimmunity? - ENS de Lyon - École normale supérieure de Lyon Accéder directement au contenu
Article Dans Une Revue Autoimmunity Reviews Année : 2017

Does type-I interferon drive systemic autoimmunity?

Résumé

Type-I interferon (IFN)-mediated immune response involves both innate and adaptive immune system and has a pivotal role in antiviral defence. A complex interplay of intracellular signaling pathways and tight regulatory systems drive the IFN activation. The observation of an aberrant stimulation of this system as a common molecular basis in peculiar inherited autoimmune and autoinflammatory disorders led to the concept of "type I interferonopathies". But the precise genetic dissection of this growing spectrum of diseases adds more and more complexity to the comprehension of this concept and a lot of unsolved questions remain such as how type I IFN can drive systemic inflammation in these clinically and genetically heterogeneous diseases.
Fichier non déposé

Dates et versions

hal-01953657 , version 1 (13-12-2018)

Identifiants

Citer

Cécile Picard, Alexandre Belot. Does type-I interferon drive systemic autoimmunity?. Autoimmunity Reviews, 2017, 16 (9), pp.897-902. ⟨10.1016/j.autrev.2017.07.001⟩. ⟨hal-01953657⟩
41 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More