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Article Dans Une Revue Obesity Année : 2021

BMI and pneumonia outcomes in critically ill COVID‐19 patients: an international multicenter study

1 RTD - Recherche translationnelle sur le diabète - U 1190
2 CINFO - Centre Intégré Nord Francilien de l'Obésité
3 METRICS - Evaluation des technologies de santé et des pratiques médicales - ULR 2694
4 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
5 HCL - Hospices Civils de Lyon
6 CIRI - Centre International de Recherche en Infectiologie
7 CarMeN - Cardiovasculaire, métabolisme, diabétologie et nutrition
8 Fondazione Policlinico Universitario Agostino Gemelli IRCCS
9 CIBERES - Centro de Investigación Biomédica en Red Enfermedades Respiratorias
10 Corporació Sanitària Parc Taulí
11 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
12 NanoRegMed - Nanomédecine Régénérative
13 IRM - Immuno-Rhumatologie Moléculaire
14 Rhode Island Hospital [Providence, RI, États-Unis]
15 Warren Alpert Medical School of Brown University
16 UniBs - Università degli Studi di Brescia = University of Brescia
17 Azienda Socio Sanitaria Territoriale Spedali Civili di Brescia [Brescia]
18 Hôpital Foch [Suresnes]
19 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
20 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
21 CHU Rouen
22 EnVI - Endothélium, valvulopathies et insuffisance cardiaque
23 ULB - Université libre de Bruxelles
24 CHU Amiens-Picardie
25 Centre Hospitalier d'Abbeville
26 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
27 ToNIC - Toulouse NeuroImaging Center
28 CH de Dunkerque
29 Albert Einstein College of Medicine [New York]
30 University of Piraeus
31 Centre Hospitalier de Roubaix
32 CHRU Brest - Centre Hospitalier Régional Universitaire de Brest
33 LaTIM - Laboratoire de Traitement de l'Information Medicale
34 Unipd - Università degli Studi di Padova = University of Padua
35 Rabin Medical Center - Beilinson and Hasharon Hospitals [Petach-Tikva, Israel]
36 TAU - Tel Aviv University
Mathilde Neuville
Emilie Occhiali
Loay Kontar
  • Fonction : Auteur
  • PersonId : 1151171
Raphael Krouchi
  • Fonction : Auteur
Victoria Dubar
  • Fonction : Auteur

Résumé

Objective: Previous studies have unveiled a relationship between the severity of coronavirus disease 2019 (COVID-19) pneumonia and obesity. The aims of this multicenter retrospective cohort study were to disentangle the association of BMI and associated metabolic risk factors (diabetes, hypertension, hyperlipidemia, and current smoking status) in critically ill patients with COVID-19. Methods: Patients admitted to intensive care units for COVID-19 in 21 centers (in Europe, Israel, and the United States) were enrolled in this study between February 19, 2020, and May 19, 2020. Primary and secondary outcomes were the need for invasive mechanical ventilation (IMV) and 28-day mortality, respectively. Results: A total of 1,461 patients were enrolled; the median (interquartile range) age was 64 years (40.9-72.0); 73.2% of patients were male; the median BMI was 28.1 kg/m2 (25.4-32.3); a total of 1,080 patients (73.9%) required IMV; and the 28-day mortality estimate was 36.1% (95% CI: 33.0-39.5). An adjusted mixed logistic regression model showed a significant linear relationship between BMI and IMV: odds ratio = 1.27 (95% CI: 1.12-1.45) per 5 kg/m2 . An adjusted Cox proportional hazards regression model showed a significant association between BMI and mortality, which was increased only in obesity class III (≥40; hazard ratio = 1.68 [95% CI: 1.06-2.64]). Conclusions: In critically ill COVID-19 patients, a linear association between BMI and the need for IMV, independent of other metabolic risk factors, and a nonlinear association between BMI and mortality risk were observed.
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Dates et versions

hal-03222408 , version 1 (20-10-2021)

Identifiants

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Mikael Chetboun, Violeta Raverdy, Julien Labreuche, Arthur Simonnet, Florent Wallet, et al.. BMI and pneumonia outcomes in critically ill COVID‐19 patients: an international multicenter study. Obesity, 2021, 29 (9), pp.1477-1486. ⟨10.1002/oby.23223⟩. ⟨hal-03222408⟩
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