Theoretical evidence of osteoblast self-inhibition after activation of the genetic regulatory network controlling mineralization - Réseau de recherche en Théorie des Systèmes Distribués, Modélisation, Analyse et Contrôle des Systèmes Access content directly
Journal Articles Journal of Theoretical Biology Year : 2022

Theoretical evidence of osteoblast self-inhibition after activation of the genetic regulatory network controlling mineralization

Abstract

Bone is a hard-soft biomaterial built through a self-assembly process under genetic regulatory network (GRN) monitoring. This paper aims to capture the behaviour of the bone GRN part that controls mineralization by using a mathematical model. Here, we provide an advanced review of empirical evidence about interactions between gene coding (i) transcription factors and (ii) bone proteins. These interactions are modelled with nonlinear differential equations using Michaelis-Menten and Hill functions. Compared to empirical evidence - coming from osteoblasts culture -, the two best systems (among 126 1⁄4 2; 985; 984 possibilities) use factors of inhibition from the start of the activation of each gene. It reveals negative indirect interactions coming from either negative feedback loops or the recently depicted micro-RNAs. The difference between the two systems also lies in the BSP equation and two ways for activating and reducing its production. Thus, it highlights the critical role of BSP in the bone GRN that acts on bone mineralization. Our study provides the first theoretical evidence of osteoblast self-inhibition after activation of the genetic regulatory network controlling mineralization with this work.
Fichier principal
Vignette du fichier
JTB_BONE_GRN.pdf (2.07 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-03924769 , version 1 (30-01-2023)

Identifiers

Cite

Abdennasser Chekroun, Laurent Pujo-Menjouet, Steve Falcoz, Kamyine Tsuen, Kevin Tsueng, et al.. Theoretical evidence of osteoblast self-inhibition after activation of the genetic regulatory network controlling mineralization. Journal of Theoretical Biology, 2022, 537, pp.111005. ⟨10.1016/j.jtbi.2022.111005⟩. ⟨hal-03924769⟩
63 View
38 Download

Altmetric

Share

Gmail Facebook X LinkedIn More